Supplementary MaterialsFigure 7source data 1: Maximum likelihood parameters for any logistic model containing an interaction term, and a random effect term describing the probability of a nucleus being present in a MyHC+ cell. model made up of an conversation term and a random effect (mouse) to describe the effect of CA RET51 (RET51-MENA) expression and Sunitinib, TG101209 or Zactima on fusion in C2C12 myoblasts. (a) Maximum likelihood parameters for any logistic model made up of an conversation term and a random effect (mouse) to describe the effect of RET51-MENA expression and Sunitinib, TG101209 or Zactima on fusion in C2C12 myoblasts. (b) Maximum likelihood parameters for any logistic model made up of an conversation term for RET51-MEN2A and Sunitinib (RET51CA:Sunitinib), Ret51-MEN2A with TG101209 (RET51CA: TG101209) or Ret5-MEN2A with Zactima?(RET51CA:Zactima) that reveals the gradient of response of myoblast fusion. Significance of interaction effects relative to the baseline (MIG control retrovirus infected cells with no drug present) is usually indicated by p values. represents the log of the?odds of the fusion index, represents the intercept parameter (representing the control treatment: MIG control retrovirus with no drug), are the parameters representing the effects of each treatment, or the conversation as specified, is a parameter representing the effect of concentration of a drug and indicates whether the effect is present or BAF312 (Siponimod) absent.DOI: http://dx.doi.org/10.7554/eLife.11405.011 elife-11405-fig8-data1.docx (141K) BAF312 (Siponimod) DOI:?10.7554/eLife.11405.011 Figure 8source data 2: Quasi-Poisson model parameters for any fixed-effects factorial model incorporating a parameter to account for the?replicate effects (Batch) on the number of cells expressing CA RET51 (RET51-MEN2A) or control when treated with different concentrations of Sunitinib, TG101209 or Zactima. The?significance of each effect and combined effects relative to the baseline (control (MIG) infected cells from Batch A with no drug present) is indicated by p values. PDGFD represents the log of the number of cells, represents the intercept parameter (representing the control treatment: MIG control retrovirus with no drug), are the parameters representing the effects of each treatment, or the conversation as specified and indicates whether the effect is present or absent.DOI: http://dx.doi.org/10.7554/eLife.11405.012 elife-11405-fig8-data2.docx (70K) DOI:?10.7554/eLife.11405.012 Figure 9Source data 1: Maximum likelihood parameters for any logistic model containing an conversation term, and a random effect term (the mouse) that BAF312 (Siponimod) describes the proportion of myoblasts transduced with DUX4 or control retrovirus and incorporating EdU when subjected to Sunitinib or DMSO. (a) Optimum likelihood variables for the logistic model formulated with an relationship term, and a arbitrary impact term (the mouse) that describes the percentage of myoblasts incorporating EdU transduced with DUX4 or control (MIG)?retrovirus when subjected to DMSO or Sunitinib. represents the likelihood of EdU incorporation. represents the intercept parameter (representing the control treatment: MIG control retrovirus without drug), will be the variables representing the consequences of every treatment, or the relationship as specified and indicates whether the effect is present or absent. (b) Corresponding log of odds ratios computed from your model, for all those 4 tested conditions.DOI: http://dx.doi.org/10.7554/eLife.11405.014 elife-11405-fig9-data1.docx (53K) DOI:?10.7554/eLife.11405.014 Physique 9Source data 2: Maximum likelihood parameters for any logistic model containing an conversation term, and a random effect term (the mouse)?that describes the proportion of cells transduced with DUX4 or control retrovirus and?expressing MyoD?when exposed to Sunitinib or DMSO. (a) Maximum likelihood parameters for any logistic model made up of an conversation term, and BAF312 (Siponimod) a random effect term (the mouse) that describes the proportion of cells expressing MyoD transduced with DUX4 or MIG control retrovirus when exposed to Sunitinib or DMSO. represents the probability of MyoD expression. represents the intercept parameter (representing the control treatment: MIG control retrovirus with no drug), are the parameters representing the effects of each treatment, or the conversation as specified and indicates whether the effect is present or absent. (b) Corresponding log of odds ratios computed from your model, for all those 4 tested conditions.DOI: http://dx.doi.org/10.7554/eLife.11405.015 elife-11405-fig9-data2.docx (50K) DOI:?10.7554/eLife.11405.015 Figure 10source data 1: Maximum likelihood parameters for any logistic model containing an interaction term between DUX4 and Sunitinib that explains the fusion index of satellite-cells grown at high density with or without DUX4 transduction. (a) Maximum likelihood parameters for any logistic model made up of an conversation term between DUX4 expression and Sunitinib during fusion of satellite-cells produced at high density and transduced with DUX4-expressing retrovirus or control?(MIG). represents the log-of-odds of the fusion index. represents the intercept parameter (representing the control treatment: no retrovirus, with no drug present), are the.